Human gd T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells
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چکیده
منابع مشابه
Licensing of γδT cells for professional antigen presentation
Following activation, γδ T cells display many properties of lymphocytes from the innate immune system, yet how they mediate antigen presentation remains an open conundrum. In humans, circulating γδ T cells that express the Vγ9Vδ2 T-cell receptor become reversibly licensed for professional antigen presentation only upon interaction with a target cell opsonized with IgGs.
متن کاملHuman γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.
Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer mo...
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